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[Critical role of IFN-alpha/beta and IFN-gamma in the regulation of airway inflammation].
- Source :
-
Nihon rinsho. Japanese journal of clinical medicine [Nihon Rinsho] 2006 Jul; Vol. 64 (7), pp. 1260-8. - Publication Year :
- 2006
-
Abstract
- Immune balance, which is controlled by IFN-gamma-producing Th1 cells and IL-4-producing Th2 cells, plays a critical role in the regulation of airway inflammation. We have demonstrated that Th1 cells induced neutrophilia, airway hyperresponsiveness (AHR) but not mucus hypersecretion, while Th2 cells induced eosinophilia, AHR and mucus hypersecretion. Here, we indicated that IFN-gamma produced by Th1 cells accelerated neutrophilia and AHR but inhibited eosinophilia and mucus hypersecretion. We also demonstrated an important role of type 1 IFN-alpha/beta during inhibition of Th2-dependent airway inflammation by TLR-9-ligand, CpG-ODN. CpG-ODN-induced IFN-alpha/beta partially appeared to act against Th2 cells to inhibit the production of IL-4 and IL-13, which are key cytokines to regulate the activation and migration of Th2 cells in the lung.
- Subjects :
- Adjuvants, Immunologic therapeutic use
Animals
Humans
Immunotherapy, Adoptive
Interferon-gamma therapeutic use
Oligodeoxyribonucleotides therapeutic use
Respiratory Hypersensitivity therapy
STAT6 Transcription Factor physiology
Th1 Cells immunology
Th2 Cells immunology
Interferon-alpha physiology
Interferon-beta physiology
Interferon-gamma physiology
Respiratory Hypersensitivity immunology
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0047-1852
- Volume :
- 64
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nihon rinsho. Japanese journal of clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16838642