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Identification of 13q deletion, trisomy 1q, and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma.
- Source :
-
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2006 Jul 15; Vol. 168 (2), pp. 124-32. - Publication Year :
- 2006
-
Abstract
- The most frequent genetic aberrations in multiple myeloma (MM) are 13q deletions and translocations involving the immunoglobulin heavy chain gene (IGH). There have been no reports on the cytogenetic abnormalities found in Korean patients with MM. We investigated the actual prevalence and prognostic value of cytogenetic changes using fluorescence in situ hybridization (FISH). FISH studies with 12 different specific probes for the regions containing the genes or chromosome regions (13q, 1q, IGH, p53, MLL, p16, CEP 7, CEP 11, and CEP 12) were performed in 128 patients. The most frequent change found was 13q deletion (48%), followed by trisomy 1q (45%), IGH translocation (37%), and trisomy 11 (26%). Among the three different probes used to detect 13q deletion, D13S25 (48/58) was the most sensitive probe compared to RB (43/58) and D13S319 (39/58). Among the patients showing one or more changes by FISH, 75% (82/110) had a 13q deletion, a trisomy 1q, or an IGH translocation. Azotemia, anemia, thrombocytopenia, intramedullary plasmacytosis, and stage were significantly associated with the 13q deletion; serum beta(2)-microglobulin, thrombocytopenia, and intramedullary plasmacytosis were also related to trisomy 1q. The pattern of molecular cytogenetic changes in Korean patients with MM is somewhat different from what has been observed in reported Caucasian populations: 37 versus 50-70% with regard to the IGH translocation. The prevalence of the 13q deletion was similar in Korean and Caucasian populations, 48 versus 30-50%. We suggest that the detection of at least these three genetic changes, 13q- trisomy 1q, and an IGH rearrangement, would be helpful for follow-up of Korean patients with MM.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Immunoglobulins genetics
In Situ Hybridization, Fluorescence
Interphase
Karyotyping
Korea
Male
Middle Aged
Multiple Myeloma ethnology
Ploidies
Regression Analysis
Sensitivity and Specificity
Survival Analysis
Tumor Cells, Cultured
Asian People genetics
Chromosome Deletion
Chromosomes, Human, Pair 1 genetics
Chromosomes, Human, Pair 13 genetics
Gene Rearrangement, B-Lymphocyte, Heavy Chain genetics
Multiple Myeloma genetics
Trisomy genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0165-4608
- Volume :
- 168
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer genetics and cytogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 16843102
- Full Text :
- https://doi.org/10.1016/j.cancergencyto.2006.02.015