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CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli.
- Source :
-
European journal of immunology [Eur J Immunol] 2006 Aug; Vol. 36 (8), pp. 2116-27. - Publication Year :
- 2006
-
Abstract
- CC chemokine ligand (CCL)17 is implicated in the pathogenesis of atopic dermatitis (AD). To study the effect of CCL17 produced by keratinocytes (KC) during inflammation, we created transgenic (Tg) mice in which CCL17 is overexpressed in KC. Th2-type contact hypersensitivity (CHS) was enhanced and Th1-type CHS was suppressed in these mice. Increased numbers of CC chemokine receptor (CCR)4(+) cells and mast cells infiltrated in Tg mice. Levels of IL-4 mRNA were higher and those of IFN-gamma mRNA were lower in both acute and chronic CHS. Higher levels of serum IgE were observed after CHS. Numbers of CCR4(+) cells among PBMC were increased in Tg mice challenged acutely on the trunk. Chronic irritation with croton oil induced dermatitis and an elevation of serum IgE levels. Tg mice showed enhanced ear swelling after tape stripping. CCL17 was thought to modify the inflammation caused by sensitizing reagents as well as irritant reagents by attracting CCR4(+) cells into the lesional skin and creating a Th2-dominant condition. AD-like conditions such as increased number of mast cells and elevated levels of serum IgE were observed. Thus, CCL17 may participate in the pathogenesis of skin diseases such as AD by regulating both allergic and irritant inflammation.
- Subjects :
- Acute Disease
Animals
Cells, Cultured
Chemokine CCL17
Chemokines, CC genetics
Chronic Disease
Croton Oil pharmacology
Dermatitis, Contact genetics
Dermatitis, Contact immunology
Dermatitis, Contact metabolism
Dermatitis, Contact pathology
Female
Gene Expression Regulation
Hypersensitivity genetics
Hypersensitivity pathology
Interferon-gamma genetics
Interleukin-4 genetics
Keratinocytes metabolism
Lymphocyte Count
Lymphocytes cytology
Lymphocytes drug effects
Lymphocytes metabolism
Male
Mice
Mice, Transgenic
Oxazoles pharmacology
RNA, Messenger
Receptors, CCR4
Receptors, Chemokine
Transcription Factors metabolism
Chemokines, CC metabolism
Hypersensitivity immunology
Hypersensitivity metabolism
Th2 Cells immunology
Th2 Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 36
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16856206
- Full Text :
- https://doi.org/10.1002/eji.200535564