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Bone mineral density in women aged 25-35 years receiving depot medroxyprogesterone acetate: recovery following discontinuation.
- Source :
-
Contraception [Contraception] 2006 Aug; Vol. 74 (2), pp. 90-9. Date of Electronic Publication: 2006 May 19. - Publication Year :
- 2006
-
Abstract
- Introduction: This 7-year, prospective, matched-cohort, clinical study evaluated the effects of intramuscular depot medroxyprogesterone acetate (DMPA) (150 mg/mL) on bone mineral density (BMD) in women aged 25-35 years.<br />Methods: Bone mineral density changes in new DMPA-IM users (n=248) were compared with those in women using nonhormonal contraception (n=360) for up to 240 weeks of treatment and 96 weeks of posttreatment follow-up (in subjects receiving >or=1 dose).<br />Results: At week 240 of treatment, mean percentage changes from baseline in DMPA-IM vs. nonhormonal subjects were: -5.16% (n=21) vs. +0.19% (n=65), total hip (p<.001); -5.38% (n=33) vs. +0.43% (n=105), lumbar spine (p<.001). At week 96 posttreatment, these values were: -0.20% (n=25) vs. +0.84% (n=43), total hip (p=.047); -1.19% (n=41) vs. +0.47% (n=66), lumbar spine (p=.017).<br />Conclusions: These results show BMD declines during DMPA-IM use; following discontinuation, significant increases in BMD occur through 96 weeks posttreatment.
- Subjects :
- Adult
Body Weight
Bone and Bones metabolism
Cohort Studies
Contraceptive Agents, Female administration & dosage
Female
Humans
Lipids blood
Medroxyprogesterone Acetate administration & dosage
Osteocalcin blood
Prospective Studies
Bone Density drug effects
Contraceptive Agents, Female adverse effects
Medroxyprogesterone Acetate adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0010-7824
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Contraception
- Publication Type :
- Academic Journal
- Accession number :
- 16860045
- Full Text :
- https://doi.org/10.1016/j.contraception.2006.03.010