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Atrial fibrillation predicts appropriate shocks in primary prevention implantable cardioverter-defibrillator patients.
- Source :
-
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [Europace] 2006 Aug; Vol. 8 (8), pp. 566-72. - Publication Year :
- 2006
-
Abstract
- Aims: Atrial fibrillation (AF) is often present in patients with left ventricular dysfunction who receive an implantable cardioverter-defibrillator (ICD). The purpose of this study was to investigate whether AF is associated with appropriate shocks and cardiovascular mortality in primary prevention ICD patients with left ventricular dysfunction.<br />Methods and Results: We included 80 primary prevention ICD patients with left ventricular dysfunction and compared the outcome between patients with a history of AF (n=29) and patients with no history of AF (n=51). The primary endpoint was occurrence of appropriate shocks. Secondary endpoints were: (1) the composite of cardiovascular mortality/appropriate shocks; and (2) inappropriate shocks. During follow-up (median 8 months, range 1-60), patients with a history of AF more often received appropriate shocks than patients with no history of AF (24 vs. 6%, P=0.03). The composite endpoint of cardiovascular mortality/appropriate shocks was also more likely to occur in patients with a history of AF (34 vs. 12%, P=0.02). History of AF predicted appropriate shocks (HR 6.9, 95% CI 1.7-27.5, P=0.006) and the composite endpoint of cardiovascular mortality/appropriate shocks (adjusted HR 5.1, 95% CI 1.7-15.1, P=0.003). There were no differences in occurrence of inappropriate shocks.<br />Conclusion: Our study demonstrates that history of AF is associated with increased risk of appropriate shocks and cardiovascular mortality in primary prevention ICD patients with left ventricular dysfunction.
- Subjects :
- Aged
Cardiovascular Diseases mortality
Endpoint Determination
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Retrospective Studies
Risk Factors
Treatment Outcome
Ventricular Dysfunction, Left physiopathology
Ventricular Dysfunction, Left therapy
Atrial Fibrillation physiopathology
Defibrillators, Implantable
Primary Prevention methods
Shock, Cardiogenic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1099-5129
- Volume :
- 8
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 16864611
- Full Text :
- https://doi.org/10.1093/europace/eul081