Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.

Authors :: Szabó D
Silveira F
Hujer AM
Bonomo RA
Hujer KM
Marsh JW
Bethel CR
Doi Y
Deeley K
Paterson DL
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2006 Aug; Vol. 50 (8), pp. 2833-5.
Publication Year :: 2006
Abstract: We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

Subjects :: Drug Resistance, Microbial genetics
Enterobacter cloacae genetics
Enterobacter cloacae isolation & purification
Ertapenem
Gene Expression Regulation, Bacterial
Genes, Bacterial
Humans
Microbial Sensitivity Tests
Transcription, Genetic
Anti-Bacterial Agents pharmacology
Bacterial Outer Membrane Proteins metabolism
Enterobacter cloacae drug effects
Membrane Transport Proteins metabolism
beta-Lactams pharmacology

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