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The role of pro-inflammatory cytokines in inflammatory bowel disease growth retardation.
- Source :
-
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2006 Aug; Vol. 43 (2), pp. 144-55. - Publication Year :
- 2006
-
Abstract
- Childhood inflammatory bowel disease (IBD) especially those with Crohn disease is commonly complicated by faltering growth and pubertal delay. Pro-inflammatory cytokines are often elevated in IBD and may affect linear growth and puberty either systemically or at the level of the growth plate. Further study of the underlying mechanisms of the deleterious effects of cytokines on the growth plate may improve management of faltering growth in childhood IBD. Well-controlled clinical studies of the respective effect of nutritional support, immunomodulatory therapy, biological agents and growth and puberty promoting agents on managing faltering growth also require further attention.
- Subjects :
- Adolescent
Body Height drug effects
Body Height physiology
Body Weight drug effects
Body Weight physiology
Child
Child, Preschool
Cytokines adverse effects
Female
Growth physiology
Growth Disorders drug therapy
Growth Hormone therapeutic use
Humans
Inflammatory Bowel Diseases metabolism
Male
Puberty, Delayed etiology
Steroids therapeutic use
Cytokines biosynthesis
Growth drug effects
Growth Disorders etiology
Inflammatory Bowel Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0277-2116
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 16877976
- Full Text :
- https://doi.org/10.1097/01.mpg.0000226374.18494.14