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Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2006 Nov 15; Vol. 14 (22), pp. 7482-9. Date of Electronic Publication: 2006 Aug 01. - Publication Year :
- 2006
-
Abstract
- A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.
- Subjects :
- Anti-Bacterial Agents chemistry
Antifungal Agents chemistry
Escherichia coli drug effects
Gram-Positive Cocci drug effects
Mannich Bases chemical synthesis
Mannich Bases chemistry
Mitosporic Fungi drug effects
Molecular Structure
Pseudomonas aeruginosa drug effects
Schiff Bases chemical synthesis
Schiff Bases chemistry
Structure-Activity Relationship
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacokinetics
Antifungal Agents chemical synthesis
Antifungal Agents pharmacokinetics
Chlorine chemistry
Fluorine chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 14
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16879972
- Full Text :
- https://doi.org/10.1016/j.bmc.2006.07.015