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Benefits of achieving the NCEP optional LDL-C goal among elderly patients with ACS.
- Source :
-
European heart journal [Eur Heart J] 2006 Oct; Vol. 27 (19), pp. 2310-6. Date of Electronic Publication: 2006 Aug 03. - Publication Year :
- 2006
-
Abstract
- Aims: To assess the efficacy and safety of the achievement of the NCEP goal of LDL-C <1.8 mmol/L in elderly patients with ACS.<br />Methods and Results: The relationship between LDL-C at 30 days after ACS and subsequent clinical outcomes were compared among elderly patients (aged > or =70 years) vs. younger counterparts in the PROVE IT-TIMI 22 trial, using the composite endpoint of death, myocardial infarction, or unstable angina. Among 634 elderly patients, the achievement of the NCEP goal was associated with an 8% absolute and a 40% relative lower risk of events [Hazard ratio (HR) 0.60, 95% confidence interval (CI) 0.41-0.87, P = 0.008] vs. corresponding benefits of 2.3 and 26% in 3150 younger patients (HR 0.74, 95% CI 0.59-0.94, P = 0.013). The estimated number of events preventable among the elderly by the achievement of these goals was 80 events at 2 years for every 1000 patients at goal vs. those not at goal, compared with 23 events potentially prevented in younger patients. The incidence of major side effects among the elderly was similar to that in younger patients and did not differ with the intensity of the statin regimen.<br />Conclusion: Among elderly ACS patients, achieving the new NCEP LDL-C optional goal as part of a secondary prevention strategy can be both as safe and effective as in younger patients.
- Subjects :
- Aged
Coronary Disease blood
Coronary Disease mortality
Double-Blind Method
Female
Hospitalization statistics & numerical data
Humans
Hyperlipidemias blood
Hyperlipidemias mortality
Male
Myocardial Infarction blood
Myocardial Infarction mortality
Myocardial Infarction prevention & control
Recurrence
Risk Factors
Treatment Outcome
Anticholesteremic Agents therapeutic use
Coronary Disease prevention & control
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hyperlipidemias prevention & control
Lipoproteins, LDL blood
Subjects
Details
- Language :
- English
- ISSN :
- 0195-668X
- Volume :
- 27
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- European heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 16887854
- Full Text :
- https://doi.org/10.1093/eurheartj/ehl180