Back to Search
Start Over
Benazepril combined with either amlodipine or hydrochlorothiazide is more effective than monotherapy for blood pressure control and prevention of end-organ injury in hypertensive Dahl rats.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2006 Jul; Vol. 48 (1), pp. 857-61. - Publication Year :
- 2006
-
Abstract
- We studied the effect of hydrochlorothiazide (HCTZ), the angiotensin-converting enzyme inhibitor benazepril, the calcium channel blocker amlodipine, or a combination of benazepril/amlodipine or benazepril/HCTZ on systolic blood pressure (BP) and end-organ injury (left ventricular hypertrophy, proteinuria, and endothelium-dependent relaxation to acetylcholine) in hypertensive Dahl salt-sensitive rats fed either a normal-salt (0.5% NaCl) or high-salt (4% NaCl) diet for 6 weeks. Rats fed a high-salt diet developed hypertension and significant end-organ injury. Monotherapy with HCTZ (75 mg/L in drinking water) or amlodipine (10 mg/kg/day by gavage) reduced systolic BP and proteinuria; benazepril (40 mg/kg/day by gavage) decreased proteinuria without significantly lowering systolic BP. In rats receiving a high-salt diet, only HCTZ reduced left ventricular hypertrophy, whereas endothelium-dependent relaxation was improved by amlodipine and benazepril but not by HCTZ. Combining benazepril with either amlodipine or HCTZ dramatically reduced systolic BP and end-organ injury. These data clearly support clinical studies suggesting that combination therapy is more effective than monotherapy for systolic BP control and prevention of end-organ injury. Complementary mechanisms of action of agents from different antihypertensive classes appear to facilitate the greater benefit on BP and end-organ injury.
- Subjects :
- Acetylcholine pharmacology
Administration, Oral
Amlodipine administration & dosage
Animals
Antihypertensive Agents administration & dosage
Benzazepines administration & dosage
Blood Pressure drug effects
Drug Therapy, Combination
Hydrochlorothiazide administration & dosage
Hypertension etiology
Hypertension physiopathology
Male
Rats
Rats, Inbred Dahl
Sodium Chloride, Dietary administration & dosage
Sodium Chloride, Dietary toxicity
Vasodilation drug effects
Amlodipine therapeutic use
Benzazepines therapeutic use
Hydrochlorothiazide therapeutic use
Hypertension prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0160-2446
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16891915
- Full Text :
- https://doi.org/10.1097/01.fjc.0000238598.09152.30