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Vanadyl sulfate protects against streptozotocin-induced morphological and biochemical changes in rat aorta.
- Source :
-
Cell biochemistry and function [Cell Biochem Funct] 2007 Nov-Dec; Vol. 25 (6), pp. 603-9. - Publication Year :
- 2007
-
Abstract
- The aim of this study was to investigate the protective effects of vanadyl sulfate on aorta tissue of normal and streptozotocin (STZ)-induced diabetic rats, morphologically and biochemically. The animals were made diabetic by an intraperitoneal injection of streptozotocin (65 mg/kg) and vanadyl sulfate (100 mg/kg) that was given every day for 60 days by gavage technique to rats. Under the light and transmission electron microscopes, hypertrophy of the vessel wall, focal disruption in the elastic lamellae, an increase in thickness of total aortic wall, tunica intima, subendothelial space and adventitial layer, and a disorganization in smooth muscular cells of the tunica media were observed in diabetic animals. The aorta lipid peroxidation (LPO) levels were significantly increased and the aorta glutathione (GSH) levels were significantly reduced in STZ diabetic rats. In diabetic rats administered vanadyl sulfate for 60 days, aorta LPO levels significantly decreased and the aorta GSH level significantly increased. In conclusion, in vivo treatment with vanadyl sulfate of diabetic rats prevented the morphological and biochemical changes observed in thoracic aorta of diabetic animals.<br /> (Copyright (c) 2006 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Aorta, Thoracic metabolism
Aorta, Thoracic pathology
Blood Glucose metabolism
Diabetes Mellitus, Experimental chemically induced
Diabetes Mellitus, Experimental pathology
Endothelium, Vascular drug effects
Endothelium, Vascular pathology
Endothelium, Vascular ultrastructure
Glutathione metabolism
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents pharmacology
Injections, Intraperitoneal
Lipid Peroxidation drug effects
Male
Microscopy, Electron
Muscle, Smooth, Vascular drug effects
Muscle, Smooth, Vascular pathology
Muscle, Smooth, Vascular ultrastructure
Rats
Streptozocin administration & dosage
Tunica Intima drug effects
Tunica Intima pathology
Tunica Intima ultrastructure
Tunica Media drug effects
Tunica Media pathology
Tunica Media ultrastructure
Vanadium Compounds administration & dosage
Aorta, Thoracic drug effects
Diabetes Mellitus, Experimental prevention & control
Streptozocin toxicity
Vanadium Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0263-6484
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cell biochemistry and function
- Publication Type :
- Academic Journal
- Accession number :
- 16892454
- Full Text :
- https://doi.org/10.1002/cbf.1354