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Characterization of the tunneling conductance across DNA bases.
- Source :
-
Physical review. E, Statistical, nonlinear, and soft matter physics [Phys Rev E Stat Nonlin Soft Matter Phys] 2006 Jul; Vol. 74 (1 Pt 1), pp. 011919. Date of Electronic Publication: 2006 Jul 28. - Publication Year :
- 2006
-
Abstract
- Characterization of the electrical properties of the DNA bases (adenine, cytosine, guanine, and thymine), in addition to building the basic knowledge on these fundamental constituents of a DNA, is a crucial step in developing a DNA sequencing technology. We present a first-principles study of the current-voltage characteristics of nucleotidelike molecules of the DNA bases, placed in a 1.5 nm gap formed between gold nanoelectrodes. The quantum transport calculations in the tunneling regime are shown to vary strongly with the electrode-molecule geometry and the choice of the density-functional theory exchange-correlation functionals. Analysis of the results in the zero-bias limit indicates that distinguishable current-voltage characteristics of different DNA bases are dominated by the geometrical conformations of the bases and nanoelectrodes.
Details
- Language :
- English
- ISSN :
- 1539-3755
- Volume :
- 74
- Issue :
- 1 Pt 1
- Database :
- MEDLINE
- Journal :
- Physical review. E, Statistical, nonlinear, and soft matter physics
- Publication Type :
- Academic Journal
- Accession number :
- 16907139
- Full Text :
- https://doi.org/10.1103/PhysRevE.74.011919