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Selective internal radiation therapy with 90Y microspheres for colorectal liver metastases: single-centre experience with 100 patients.
- Source :
-
ANZ journal of surgery [ANZ J Surg] 2006 Aug; Vol. 76 (8), pp. 696-703. - Publication Year :
- 2006
-
Abstract
- Background: Many patients with colorectal liver metastases die from liver-only disease. Selective internal radiation therapy (SIRT) is an evolving method suitable for treating patients with non-resectable metastatic liver disease.<br />Methods: One hundred patients with advanced colorectal liver metastases were treated with SIRT. A single dose of between 2.0 and 3.0 GBq of (90)Y microspheres was given into the hepatic artery either by a surgically implanted portacath or a percutaneous femoral catheter. When a port was used (n = 87), SIRT was followed by hepatic arterial chemotherapy with 5-fluorouracil.<br />Results: Treatment-related morbidity occurred in 11 patients. Responses to SIRT were assessed by serial computed tomography scans and carcinoembryonic antigen (CEA) measurement. Median CEA level 3 months after SIRT (expressed as percentage of initial CEA) was 18%. Only 5 of 80 patients (6.25%) scanned at 3 months showed disease progression. Survival was significantly more in those who experienced a good tumour marker response and in those who were slow to develop extrahepatic disease. Survival was independently influenced by the use of ongoing hepatic arterial chemotherapy, the extent of liver involvement and the lymph node status of the original primary tumour.<br />Conclusion: Selective internal radiation therapy is a very effective and well-tolerated regional treatment for colorectal liver metastases, which should be considered for those with liver-only metastatic disease.
- Subjects :
- Adult
Aged
Carcinoembryonic Antigen blood
Colorectal Neoplasms blood
Colorectal Neoplasms mortality
Female
Humans
Infusions, Intra-Arterial
Liver Neoplasms blood
Male
Microspheres
Middle Aged
Retrospective Studies
Survival Rate
Treatment Outcome
Colorectal Neoplasms pathology
Liver Neoplasms radiotherapy
Liver Neoplasms secondary
Yttrium Radioisotopes administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1445-1433
- Volume :
- 76
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- ANZ journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 16916386
- Full Text :
- https://doi.org/10.1111/j.1445-2197.2006.03834.x