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Association of pretreatment thrombocytosis with disease progression and survival in oral squamous cell carcinoma.
- Source :
-
Oral oncology [Oral Oncol] 2007 Mar; Vol. 43 (3), pp. 283-8. Date of Electronic Publication: 2006 Aug 22. - Publication Year :
- 2007
-
Abstract
- The objective of this study was to review the prevalence and prognostic impact of pretreatment thrombocytosis in patients with oral squamous cell carcinoma (OSCC). Medical records of 253 patients with OSCC were retrospectively reviewed. The relationship between the platelet count, TNM stage, histologic differentiation, recurrence rate, metastasis, and survival were analyzed. Pretreatment thrombocytosis was found in 61 (24.1%) of 253 patients and was associated with aggressive tumour growth (p=0.015), lymph node metastasis (p=0.009), and distant metastasis (p=0.001). Association with tumour recurrence fell just short of statistical significance (p=0.058). Patients with preoperative thrombocytosis had a poorer survival than those with normal platelet counts (p=0.004). Multivariate analysis using Cox's proportional hazards model indicated that thrombocytosis was an independent predictor of shorter survival (RR 2.48, 95% CI 1.30- 4.73, p=0.006).
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell secondary
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mouth Neoplasms pathology
Neoplasm Metastasis
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Platelet Count
Retrospective Studies
Thrombocytosis pathology
Carcinoma, Squamous Cell mortality
Mouth Neoplasms mortality
Thrombocytosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1368-8375
- Volume :
- 43
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16920387
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2006.03.010