Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia.

Authors :: Sanotskaya NV
Matsievskii DD
Lebedeva MA
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Jan; Vol. 141 (1), pp. 12-6.
Publication Year :: 2006
Abstract: Acute experiments on narcotized rats showed that intravenous infusion of GABA derivative lithium hydroxybutyrate induced different changes in hemodynamic and respiratory parameters in animals with high and low resistance to hypoxia. Rats highly resistant to hypoxia better tolerated lithium hydroxybutyrate treatment compared to low resistant animals.

Subjects :: Animals
Drug Tolerance
Hydroxybutyrates administration & dosage
Hydroxybutyrates chemistry
Infusions, Intravenous
Male
Organometallic Compounds administration & dosage
Organometallic Compounds chemistry
Rats
gamma-Aminobutyric Acid chemistry
gamma-Aminobutyric Acid metabolism
Adaptation, Physiological
Hemodynamics drug effects
Hydroxybutyrates pharmacology
Hypoxia physiopathology
Organometallic Compounds pharmacology
Respiration drug effects

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