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p16INK4a and laminin-5gamma2 chain expression during the progression of cervical neoplasia.
- Source :
-
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2006; Vol. 45 (6), pp. 676-84. - Publication Year :
- 2006
-
Abstract
- p16INK4a, laminin-5gamma2 chain, and PCNA were investigated to compare the expression levels in relation to histological diagnosis and time for progression. The material consisted of 37 normal cervical tissues, 35 with different grades of CIN, and 11 invasive cervical cancers. Our results showed a reduction of basement membrane staining for laminin-5gamma2 chain from 78.4% in normal squamous epithelium to 27.8% in CIN3 (p < 0.001). The intracytoplasmic staining for laminin-5gamma2 chain increases with severity of lesion. The same trend was observed with p16INK4a and PCNA expression (p < 0.001). Co-expression of p16INK4a and PCNA was seen in 85.7% of samples. Cases that were laminin-5gamma2 chain BM - /p16INK4a+/PCNA+ have the shortest interval time (average: 46.8+/-36.3 months) for progression, while cases with laminin-5gamma2 chain BM + /p16INK4a-/PCNAPCNA--have the longest time interval (average: 110.2+/-52.7 months) (p < 0.05). Thus co-expression of p16INK4a, laminin-5gamma2 chain and PCNA may be valuable for the prediction progression of cervical neoplasia.
- Subjects :
- Adult
Basement Membrane metabolism
Biomarkers, Tumor genetics
Cell Adhesion Molecules genetics
Cyclin-Dependent Kinase Inhibitor p16 genetics
Disease Progression
Female
Humans
Immunohistochemistry
Middle Aged
Proliferating Cell Nuclear Antigen metabolism
Sweden
Time Factors
Kalinin
Biomarkers, Tumor metabolism
Cell Adhesion Molecules metabolism
Cyclin-Dependent Kinase Inhibitor p16 metabolism
Gene Expression Regulation, Neoplastic
Uterine Cervical Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0284-186X
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta oncologica (Stockholm, Sweden)
- Publication Type :
- Academic Journal
- Accession number :
- 16938810
- Full Text :
- https://doi.org/10.1080/02841860600617092