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A comparison between sodium alginate and magaldrate anhydrous in the treatment of patients with gastroesophageal reflux symptoms.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2006 Nov; Vol. 51 (11), pp. 1904-9. Date of Electronic Publication: 2006 Sep 15. - Publication Year :
- 2006
-
Abstract
- The aims of the present study were to compare effects of sodium alginate and the antacid magaldrate anhydrous in adults with gastroesophageal reflux (GOR) symptoms. Patients with heartburn and/or acid regurgitation for at least 3 days in the week before the study started (n=203) were randomized to receive a single dose of sodium alginate or magaldrate anhydrous at the onset of symptoms during a 3-day run-in period. Patients with symptoms during the run-in (n=191) were rerandomized to receive a 14-day treatment with either drug given as four daily doses. A speed of action < or =30 min was significantly more frequent among patients in the alginate group (49.4% vs. 40.4%; P=0.0074). A trend toward a more prolonged duration of action (median: 16.5 vs. 12.7 hr) and a greater sum of the symptom intensity difference (median: 40.0 vs. 31.0) was observed in the sodium alginate group. Total disappearance of symptoms was reported in 81.6% and 73.9% of patients in the sodium alginate group and magaldrate group, respectively. We conclude that sodium alginate was faster than magaldrate in relieving GRO symptoms and showed a tendency toward a more prolonged duration of action and a higher level of efficacy.
- Subjects :
- Adolescent
Alginates administration & dosage
Aluminum Hydroxide administration & dosage
Antacids administration & dosage
Drug Carriers administration & dosage
Glucuronic Acid administration & dosage
Glucuronic Acid therapeutic use
Hexuronic Acids administration & dosage
Hexuronic Acids therapeutic use
Humans
Magnesium Hydroxide administration & dosage
Prospective Studies
Treatment Outcome
Alginates therapeutic use
Aluminum Hydroxide therapeutic use
Antacids therapeutic use
Drug Carriers therapeutic use
Gastroesophageal Reflux drug therapy
Magnesium Hydroxide therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 51
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16977507
- Full Text :
- https://doi.org/10.1007/s10620-006-9284-0