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Drug distribution and stability in extemporaneous preparations of meloxicam and carprofen after dilution and suspension at two storage temperatures.

Authors :
Hawkins MG
Karriker MJ
Wiebe V
Taylor IT
Kass PH
Source :
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2006 Sep 15; Vol. 229 (6), pp. 968-74.
Publication Year :
2006

Abstract

Objective: To determine dispersion uniformity and stability of meloxicam and carprofen in extemporaneous preparations stored for 28 days.<br />Design: Prospective study.<br />Sample Population: Meloxicam and carprofen (commercial formulations) were compounded (day 0) with deionized water (DW), 1% methylcellulose gel (MCG), MCG and simple syrup (SS; 1:1 mixture), or a suspending and flavoring vehicle combination (SFVC; 1:1 mixture) to nominal drug concentrations of 0.25, 0.5, or 1.0 mg/mL and 1.25, 2.5, or 5.0 mg/mL, respectively.<br />Procedures: Preparations were stored at approximately 4 degrees C (39.2 degrees F) or 22 degrees C (71.6 degrees F). For each preparation, drug concentrations were determined and drug stability was evaluated at intervals during storage; on days 0 and 28, pH values were measured and bacterial cultures were initiated.<br />Results: In meloxicam-DW, meloxicam-MCG (0.25 mg/mL), and meloxicam-MCG (0.5 mg/mL) preparations, drug distribution was uniform (coefficient of variation < 10%); > 90% of the original drug concentration was maintained for 28 days. Despite uniform drug distribution of the carprofen-SFVC preparations, most retained > or = 90% of the original drug concentration for only 21 days. Use of the MCG-SS combination resulted in foamy preparations of unacceptable variability. After 28 days, pH decreased slightly in meloxicam-DW and meloxicam-MCG preparations (0.17 +/- 0.04 and 0.21 +/- 0.04, respectively). Carprofen-SFVC (2.5 mg/mL) and carprofen-MCG-SS (5.0 mg/mL) preparations stored at 22 degrees C for 28 days yielded bacterial growth.<br />Conclusions and Clinical Relevance: DW, MCG, and the SFVC can be used successfully for extemporaneous preparation of meloxicam and carprofen for administration to small exotic animals. Refrigeration is recommended for preparations of meloxicam-DW and carprofen-SFVC.

Details

Language :
English
ISSN :
0003-1488
Volume :
229
Issue :
6
Database :
MEDLINE
Journal :
Journal of the American Veterinary Medical Association
Publication Type :
Academic Journal
Accession number :
16978116
Full Text :
https://doi.org/10.2460/javma.229.6.968