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Three-year clinical follow-up of the unrestricted use of sirolimus-eluting stents as part of the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital (RESEARCH) registry.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2006 Oct 01; Vol. 98 (7), pp. 895-901. Date of Electronic Publication: 2006 Aug 07. - Publication Year :
- 2006
-
Abstract
- Sirolimus-eluting stents (SESs) have been shown to decrease restenosis compared with bare metal stents (BMSs). Currently, there are limited data on the long-term efficacy of these devices in a real-world patient population. Furthermore, the potential of a late restenotic phenomenon has not yet been excluded. From April to October 2002, 508 consecutive patients with de novo lesions exclusively treated with SESs were enrolled and compared with 450 patients treated with BMSs in the preceding 6 months (control group). Patients in the SES group more frequently had multivessel disease and type C lesions, received more stents, and had more bifurcation stenting. After 3 years, the cumulative incidence of major adverse cardiac events (comprising death, myocardial infarction, and target vessel revascularization) was significantly lower in the SES group compared with the pre-SES group (18.9% vs 24.7%, hazards ratio 0.73, 95% confidence interval 0.56 to 0.96, p = 0.026). The 3-year risk of target lesion revascularization was 7.5% in the SES group versus 12.6% in the pre-SES group (hazards ratio 0.57, 95% confidence interval 0.38 to 0.87, p = 0.01). In conclusion, the unrestricted use of SESs is safe and superior to the use of BMSs. The beneficial effects, reported after 1 and 2 years in reducing major adverse cardiac events, persisted with no evidence of a clinical late restenotic "catch-up" phenomenon.
- Subjects :
- Age Factors
Angina, Unstable epidemiology
Angioplasty, Balloon
Case-Control Studies
Diabetes Mellitus epidemiology
Female
Follow-Up Studies
Humans
Hypertension epidemiology
Male
Middle Aged
Myocardial Infarction epidemiology
Myocardial Revascularization
Netherlands epidemiology
Prosthesis Design
Registries
Regression Analysis
Shock, Cardiogenic epidemiology
Coronary Restenosis prevention & control
Immunosuppressive Agents administration & dosage
Sirolimus administration & dosage
Stents
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 98
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 16996869
- Full Text :
- https://doi.org/10.1016/j.amjcard.2006.04.031