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Neuronal activation in the hypothalamus and brainstem during feeding in rats.
- Source :
-
Cell metabolism [Cell Metab] 2006 Oct; Vol. 4 (4), pp. 313-21. - Publication Year :
- 2006
-
Abstract
- We trained rats to a regime of scheduled feeding, in which food was available for only 2 hr each day. After 10 days, rats were euthanized at defined times relative to food availability, and their brains were analyzed to map Fos expression in neuronal populations to test the hypothesis that some populations are activated by hunger whereas others are activated by satiety signals. Fos expression accompanied feeding in several hypothalamic and brainstem nuclei. Food ingestion was critical for Fos expression in noradrenergic and non-noradrenergic cells in the nucleus tractus solitarii and area postrema and in the supraoptic nucleus, as well as in melanocortin-containing cells of the arcuate nucleus. However, anticipation of food alone activated other neurons in the arcuate nucleus and in the lateral and ventromedial hypothalamus, including orexin neurons. Thus orexigenic populations are strongly and rapidly activated at the onset of food presentation, followed rapidly by activity in anorexigenic populations when food is ingested.
- Subjects :
- Animals
Brain Stem ultrastructure
Eating
Hypothalamus ultrastructure
Immunohistochemistry
Male
Neurons ultrastructure
Proto-Oncogene Proteins c-fos biosynthesis
Proto-Oncogene Proteins c-fos genetics
Rats
Rats, Sprague-Dawley
Time Factors
Brain Stem metabolism
Feeding Behavior physiology
Hypothalamus metabolism
Neurons metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1550-4131
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 17011504
- Full Text :
- https://doi.org/10.1016/j.cmet.2006.08.003