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Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2006 Oct 15; Vol. 177 (8), pp. 5226-35. - Publication Year :
- 2006
-
Abstract
- CD1d-restricted NKT cells expressing invariant TCR alpha-chains (iNKT cells) produce both proinflammatory and anti-inflammatory cytokines rapidly upon activation, and are believed to play an important role in both host defense and immunoregulation. To address the potential implications of iNKT cell responses for infectious or inflammatory diseases of the nervous system, we investigated the expression of CD1d in human peripheral nerve. We found that CD1d was expressed on the surface of Schwann cells in situ and on primary or immortalized Schwann cell lines in culture. Schwann cells activated iNKT cells in a CD1d-dependent manner in the presence of alpha-galactosylceramide. Surprisingly, the cytokine production of iNKT cells stimulated by alpha-galactosylceramide presented by CD1d+ Schwann cells showed a predominance of Th2-associated cytokines such as IL-5 and IL-13 with a marked deficiency of proinflammatory Th1 cytokines such as IFN-gamma or TNF-alpha. Our findings suggest a mechanism by which iNKT cells may restrain inflammatory responses in peripheral nerves, and raise the possibility that the expression of CD1d by Schwann cells could be relevant in the pathogenesis of infectious and inflammatory diseases of the peripheral nervous system.
- Subjects :
- Antigens, CD1d
Cells, Cultured
Coculture Techniques
Cytokines analysis
Galactosylceramides pharmacology
Humans
Immunity
Inflammation
Killer Cells, Natural cytology
Nervous System Diseases immunology
Nervous System Diseases pathology
Schwann Cells chemistry
Schwann Cells cytology
T-Lymphocytes
Antigens, CD1 analysis
Cell Communication immunology
Killer Cells, Natural immunology
Schwann Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 177
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 17015708
- Full Text :
- https://doi.org/10.4049/jimmunol.177.8.5226