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Cotinine concentration in smokers from different countries: relationship with amount smoked and cigarette type.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2006 Oct; Vol. 15 (10), pp. 1799-804. Date of Electronic Publication: 2006 Oct 04. - Publication Year :
- 2006
-
Abstract
- This four-country study examined salivary cotinine as a marker for nicotine intake and addiction among smokers in relation to numbers and types of cigarettes smoked. Smoking characteristics of cigarette smokers in Brazil, China, Mexico, and Poland were identified using a standard questionnaire. Cotinine concentration was measured using a saliva sample from each participant; its relationship with numbers and types of cigarettes smoked was quantified by applying regression techniques. The main outcome measure was salivary cotinine level measured by gas chromatography. In all four countries, cotinine concentration increased linearly with cigarettes smoked up to 20 per day [11.3 ng/mL (95% confidence interval, 10.5-12.2)] and then stabilized as the number of cigarettes exceeded 20 [6.8 ng/mL per cigarette (95% confidence interval, 6.3-7.4) for up to 40 cigarettes]. On average, smokers of regular cigarettes consumed more cigarettes and had higher cotinine levels than light cigarette smokers. Cotinine concentration per cigarette smoked did not differ between regular and light cigarette smokers. Results suggest a saturation point for daily nicotine intake and minimal or no reduction in nicotine intake by smoking light cigarettes.
- Subjects :
- Adolescent
Adult
Aged
Behavior, Addictive
Biomarkers analysis
Brazil epidemiology
China epidemiology
Chromatography, Gas
Female
Humans
Linear Models
Male
Mexico epidemiology
Middle Aged
Nicotine administration & dosage
Nicotine analysis
Nicotinic Agonists administration & dosage
Nicotinic Agonists analysis
Poland epidemiology
Saliva chemistry
Sampling Studies
Smoking metabolism
Surveys and Questionnaires
Tars analysis
Cotinine analysis
Smoking epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1055-9965
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 17021350
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-06-0427