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The molecular basis of colorectal carcinogenesis.
- Source :
-
Current opinion in gastroenterology [Curr Opin Gastroenterol] 1999 Jan; Vol. 15 (1), pp. 3-8. - Publication Year :
- 1999
-
Abstract
- The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.
Details
- Language :
- English
- ISSN :
- 0267-1379
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current opinion in gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 17023910
- Full Text :
- https://doi.org/10.1097/00001574-199901000-00002