Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage.

Authors :: Wasserman D
Geijer T
Sokolowski M
Frisch A
Michaelovsky E
Weizman A
Rozanov V
Wasserman J
Source :: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2007 Feb; Vol. 17 (3), pp. 230-3. Date of Electronic Publication: 2006 Oct 09.
Publication Year :: 2007
Abstract: Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n=85). Comparing the presence of SS with SL+LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (chi2=9.054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.

Subjects :: Adult
Alleles
DNA genetics
Female
Genotype
Humans
Male
Psychiatric Status Rating Scales
Polymorphism, Genetic genetics
Promoter Regions, Genetic genetics
Serotonin Plasma Membrane Transport Proteins genetics
Suicide, Attempted psychology

Language :: English
ISSN :: 0924-977X
Volume :: 17
Issue :: 3
Database :: MEDLINE
Journal :: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Publication Type :: Academic Journal
Accession number :: 17029913
Full Text :: https://doi.org/10.1016/j.euroneuro.2006.08.006

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