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Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity.
- Source :
-
Biogerontology [Biogerontology] 2007 Apr; Vol. 8 (2), pp. 139-45. Date of Electronic Publication: 2006 Sep 20. - Publication Year :
- 2007
-
Abstract
- Genes involved in cardiovascular diseases (CVD) play an opposite role in human longevity. The alpha1-antitrypsin (AAT) is a serine-protease inhibitor required for the prevention of proteolytic tissue damage, by neutrophil elastase. The role of AAT in CVD has not been definitively assessed and its effect on longevity has not yet fully been studied. To clarify these points, we have studied the distribution of AAT allele variants in 3 cohorts: 127 young patients affected by acute myocardial infarction (AMI), 255 young controls and 143 centenarians from Sicily. The Z allele frequency was most frequent in centenarians (13.3%), intermediate in healthy young controls (3.1%) and less frequent in AMI patients (1.2%) (P = 0.0000001). The heterozygous MZ genotype was significantly over represented in centenarians (38/143) and under represented in AMI patients (3/127) with intermediate values in young controls (16/255) (P = 0.0000001). After adjustment for well-recognized AMI risk factors, the MZ genotype still predicted a significant negative risk factor for developing AMI in the Sicilian population. Thus, our data show a positive role of MZ heterozygosity in attainment of successful ageing linked to the positive effects of this genotype versus the cardiovascular ischemic diseases.
- Subjects :
- Adult
Aged, 80 and over
Case-Control Studies
Cohort Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Logistic Models
Male
Middle Aged
Risk Assessment
Risk Factors
Sicily
Aging genetics
Heterozygote
Longevity genetics
Myocardial Infarction genetics
alpha 1-Antitrypsin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1389-5729
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biogerontology
- Publication Type :
- Academic Journal
- Accession number :
- 17048073
- Full Text :
- https://doi.org/10.1007/s10522-006-9041-y