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[Review about mechanisms of anti-cancer of Solanum nigrum].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2006 Aug; Vol. 31 (15), pp. 1225-6, 1260. - Publication Year :
- 2006
-
Abstract
- This paper gave a brief introduction of the effect of Solanum nigrum on anti-cancer. The experimental results showed that the total alkaloid isolated from S. nigrum interfered structure and function of tumor cell membrane, disturbed the synthesis of DNA and RNA, changed the cell cycle distribution, so that total alkaloids could play in inhibabition to tumor cells, while the glycoprotein (150 x 10(3)) isolated from S. nigrum might have shown anti-cancer abilities by blocking the anti-apoptotic pathway of NF-kappaB, activating caspase cascades reaction and increasing the production of nitric oxide.
- Subjects :
- Alkaloids isolation & purification
Animals
Antineoplastic Agents, Phytogenic isolation & purification
Caspase 3 metabolism
Cell Line, Tumor
Cell Membrane Permeability drug effects
DNA, Neoplasm biosynthesis
Drugs, Chinese Herbal isolation & purification
Glycoproteins isolation & purification
Humans
NF-kappa B metabolism
Nitric Oxide metabolism
Plants, Medicinal chemistry
RNA, Neoplasm biosynthesis
Sialic Acids metabolism
Alkaloids pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Drugs, Chinese Herbal pharmacology
Glycoproteins pharmacology
Solanum nigrum chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 31
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 17048560