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Interleukin-10 - 1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection.
- Source :
-
Journal of hepatology [J Hepatol] 2006 Dec; Vol. 45 (6), pp. 779-85. Date of Electronic Publication: 2006 Sep 22. - Publication Year :
- 2006
-
Abstract
- Background/aims: In this study, we determined the genotypic and allelic frequencies of the Interleukin (IL)-10(-1082G/A) IL-10(-592A/C), and IL-10(-819C/T) polymorphisms, and their association with the risk to develop B cell Non Hodgkin Lymphoma (NHL) in hepatitis virus C (HCV) carriers.<br />Results: Genetic polymorphisms in the IL-10 gene promoter were studied in 250 consecutive patients with B-cell NHL with no clinical and/or laboratory findings of cryoglobulinemia, 142 NHL/HCV- and 108 NHL/HCV+ with chronic hepatitis (CH), 120 consecutive subjects with HCV-related CH, and 110 age, sex-matched healthy blood donors. The frequency of the IL-10(-1082GG) genotype vs remaining genotypes (IL-10(-1082GA/AA)) was higher in NHL/HCV+ patients than HCV-related CH patients (P=0.0002, OR=2.89, CI: 1.62-5.15) and in NHL/HCV+ than NHL/HCV- patients (P=0.0001, OR=2.99, CI: 1.72-5.19). Moreover, the IL-10(-1082GG) genotype was more prevalent in indolent NHL/HCV+ cases than aggressive NHL/HCV+ (P=0.0004, OR=4.97, CI: 2.10-11.79). Finally, we confirmed that IL-10(-1082GG) genotype is associated with higher IL-10 production compared to AA homozygous (P=0.037).<br />Conclusions: The high IL-10 production, due to IL-10(-1082GG) genotype, influences the clinical expression of the HCV infection by increasing susceptibility to develop NHL and might contribute to the indolent form of the disease.
- Subjects :
- Adult
Aged
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-10 biosynthesis
Lymphoma, B-Cell epidemiology
Lymphoma, B-Cell etiology
Lymphoma, B-Cell genetics
Male
Middle Aged
Polymerase Chain Reaction
Prognosis
RNA, Viral analysis
Retrospective Studies
Risk Factors
DNA genetics
Hepatitis C, Chronic complications
Hepatitis C, Chronic epidemiology
Hepatitis C, Chronic genetics
Interleukin-10 genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8278
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 17049666
- Full Text :
- https://doi.org/10.1016/j.jhep.2006.07.026