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[Pilot experience in Russia with external contrapulsation in patients with coronary heart disease].
- Source :
-
Terapevticheskii arkhiv [Ter Arkh] 2006; Vol. 78 (9), pp. 27-33. - Publication Year :
- 2006
-
Abstract
- Aim: To examine effects of programmed external contrapulsation (ECP) on the clinico-functional status, quality of life (QOL) in patients with coronary heart disease (CHD), stable angina of FC II-IV resistant to medication.<br />Material and Methods: Eighteen patients with CHD, stable angina of FC III-IV (2 females and 16 males, mean age 63.6 +/- 7.4 years) have completed a course of ECP including 35 one-hour procedures 5-6 times a week for 7 weeks. Ten patients had cardiac failure (NYHA FC II-III). Before and after ECP course the patients were examined using QOL assessment by Minnesota questionnaire, complex echo-cardiography, bicycle exercise test, perfusion myocardial scintigraphy with 99m-Tc-4,2-methoxy-isobutilisonitril, 24-h Holter ECG monitoring, enzyme immunoassay for plasma natriuretic propeptides.<br />Results: Significant subjective QOL improvement (p < 0.01) was noticed by all the patients. Anginal attacks and nitrates doses reduced at least 2-fold. Exercise tolerance rose significantly (p < 0.01), bicycle exercise test was positive in 5 patients, the rest stopped the test after achievement of submaximal heart rate (HR) and fatigue. Most of the patients exhibited improvement of myocardial perfusion. Patients with abnormal myocardial contractility showed a moderate trend (p < 0.03) to an increase in left ventricular ejection fraction. By 24-h ECG, mean HR diminished significantly (p < 0.02).<br />Conclusion: ECP is highly effective and safe in combined therapy of CHD, stable angina resistant to drug therapy, in impossibility of myocardial revascularization, including patients with cardiac failure. This manifests in a significant abatement of angina, lower doses of nitrates, improvement of exercise tolerance, quality of life, myocardial perfusion and hemodynamic indices.
- Subjects :
- Coronary Angiography
Coronary Disease diagnosis
Coronary Disease physiopathology
Echocardiography
Electrocardiography, Ambulatory
Exercise Test
Female
Follow-Up Studies
Heart Rate physiology
Humans
Male
Middle Aged
Myocardial Contraction physiology
Pilot Projects
Stroke Volume physiology
Treatment Outcome
Coronary Disease therapy
Counterpulsation methods
Subjects
Details
- Language :
- Russian
- ISSN :
- 0040-3660
- Volume :
- 78
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Terapevticheskii arkhiv
- Publication Type :
- Academic Journal
- Accession number :
- 17076221