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Astressin B, a corticotropin-releasing hormone receptor antagonist, accelerates the return to normal luteal function after an inflammatory-like stress challenge in the rhesus monkey.
- Source :
-
Endocrinology [Endocrinology] 2007 Feb; Vol. 148 (2), pp. 841-8. Date of Electronic Publication: 2006 Nov 02. - Publication Year :
- 2007
-
Abstract
- Endogenous release of CRH in stress has been associated with a dysfunctional reproductive endocrine axis. In the rhesus monkey, an inflammatory-like stress challenge in the luteal phase decreases luteal secretory function. Here, we tested the effectiveness of astressin B, a nonspecific CRH receptor antagonist, in constraining the deleterious impact of a 10-d lipopolysaccharide (LPS) challenge on the menstrual cycle. Two protocols were carried out in nine animals. In the first, the animals, after showing two normal consecutive control cycles, were injected daily for 10 days with LPS (75-125 mug/d) during the luteal phase of the cycle. The animals were followed through the two postchallenge cycles. The second protocol, carried out in the following year, was identical with protocol 1, except that the animals were treated with astressin B (0.45 mg/kg) 1 h before each daily LPS challenge during the luteal phase. Blood samples were obtained daily to document cyclic hormones levels. The LPS challenge significantly decreased luteal progesterone and LH release during the challenge cycle. Inhibition of luteal progesterone extended to the two successive postchallenge cycles. Astressin B treatment prevented luteal LH but not luteal progesterone decrease during the treatment cycle and restored normal progesterone secretion during the two posttreatment cycles. We conclude that the deleterious impact of a short-term inflammatory stress challenge on luteal function is far longer than the stress period itself. Systemic administration of astressin B accelerates the return to normal luteal function, presumably by restoring normal neuroendocrine regulation of gonadotropin secretion.
- Subjects :
- Animals
Eating drug effects
Female
Gonadotropins metabolism
Hydrocortisone metabolism
Inflammation chemically induced
Injections, Intravenous
Lipopolysaccharides administration & dosage
Lipopolysaccharides antagonists & inhibitors
Luteal Phase
Macaca mulatta
Menstrual Cycle drug effects
Recovery of Function
Stress, Physiological chemically induced
Time Factors
Corpus Luteum drug effects
Corpus Luteum metabolism
Corticotropin-Releasing Hormone pharmacology
Inflammation metabolism
Lipopolysaccharides pharmacology
Peptide Fragments pharmacology
Receptors, Corticotropin-Releasing Hormone antagonists & inhibitors
Stress, Physiological metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0013-7227
- Volume :
- 148
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 17082255
- Full Text :
- https://doi.org/10.1210/en.2006-1074