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Leukocytosis and retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide.
- Source :
-
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih [Chin Med Sci J] 2006 Sep; Vol. 21 (3), pp. 171-4. - Publication Year :
- 2006
-
Abstract
- Objective: To study the incidence of leukocytosis and retinoic acid (RA) syndrome in newly diagnosed and relapsed acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (ATO).<br />Methods: Thirty patients with newly diagnosed or relapsed APL received ATO for remission induction at the dose of 10 mg/d. RA syndrome was defined when patient was with one or more of the following signs or symptoms: fever, dyspnea, serous cavity effusion, muscular pain, pulmonary infiltration, weight gain, or pulmonary infiltration on chest X-ray.<br />Results: Twenty-three (77% ) patients achieved complete remission, mean time to remission was 37.1 days. Leukocytosis was observed in 14 (47%) patients, mean time to leukocytosis was 12.7 days, median baseline leukocyte count for patients with leukocytosis was 3.1 x 10(9)/L, which was higher than that for patients who did not develop leukocytosis (2.6 x 10(9)/L, z = -2.635, P = 0.008). No other cytotoxic therapy was administered, and the leukocytosis resolved in all cases. The RA syndrome was observed in 9 (30%) patients, mean time to diagnose of RA syndrome was 13.9 days, median baseline leukocyte count for patients with RA syndrome was 3.6 x 10(9)/L, which was higher than that for patients who did not develop RA syndrome (2.6 x 10(9)/L, z = -1.909, P = 0.046). No patient died of RA syndrome.<br />Conclusion: Leukocytosis and RA syndrome are associated with ATO and baseline leukocyte count respectively, and there is distinct link between leukocytosis and RA syndrome.
- Subjects :
- Adolescent
Adult
Aged
Antineoplastic Agents therapeutic use
Arsenic Trioxide
Arsenicals therapeutic use
Dyspnea chemically induced
Female
Fever chemically induced
Humans
Leukocyte Count
Male
Middle Aged
Oxides therapeutic use
Remission Induction
Syndrome
Antineoplastic Agents adverse effects
Arsenicals adverse effects
Leukemia, Promyelocytic, Acute drug therapy
Leukocytosis chemically induced
Oxides adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1001-9294
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
- Publication Type :
- Academic Journal
- Accession number :
- 17086739