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Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases (review).
- Source :
-
International journal of molecular medicine [Int J Mol Med] 2006 Dec; Vol. 18 (6), pp. 1011-8. - Publication Year :
- 2006
-
Abstract
- Growth disorders are commonly observed in children suffering from chronic inflammatory diseases such as Juvenile Idiopathic Arthritis (JIA) and Inflammatory Bowel Disease (IBD). These disorders range from general growth retardation to local acceleration of growth in the affected limb and are associated with the increased production of pro-inflammatory cytokines. In this article, we review how cytokines influence child growth by exerting a local effect at the level of the growth plate, and through systemic effects throughout the whole body.
- Subjects :
- Arthritis, Juvenile complications
Child
Chronic Disease
Growth Disorders etiology
Growth Hormone physiology
Growth Plate physiopathology
Humans
Inflammatory Bowel Diseases complications
Insulin-Like Growth Factor I physiology
Arthritis, Juvenile physiopathology
Cytokines physiology
Growth Disorders physiopathology
Inflammatory Bowel Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1107-3756
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 17089003
- Full Text :
- https://doi.org/10.3892/ijmm.18.6.1011