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An observational study of vasopressin infusion during uncontrolled haemorrhagic shock in a porcine trauma model: Effects on bowel function.
- Source :
-
Resuscitation [Resuscitation] 2007 Jan; Vol. 72 (1), pp. 145-8. Date of Electronic Publication: 2006 Nov 09. - Publication Year :
- 2007
-
Abstract
- The effects of vasopressin on the gut in a porcine uncontrolled haemorrhagic shock model are described. In eight anaesthetised pigs, a liver laceration was performed; when haemorrhagic shock was decompensated, all animals received 0.4 IU/kg vasopressin, followed by 0.08 IU/kg min over 30 min, which maintained a mean arterial blood pressure >40 mmHg. Subsequent surgical intervention, infusion of whole blood and fluids resulted in a stable cardiocirculatory status. Three hours after stabilisation, all pigs developed non-bloody diarrhoea which converted into normal bowel movements within 24 h. All histological samples retained 7 days after the experiment revealed no histopathological changes. In conclusion, in this small observational study of uncontrolled porcine haemorrhagic shock, a resuscitation strategy that included high dose vasopressin was associated with transient diarrhoea and good long term survival.
- Subjects :
- Animals
Blood Pressure drug effects
Diarrhea physiopathology
Disease Models, Animal
Liver injuries
Shock, Hemorrhagic physiopathology
Swine
Vasoconstrictor Agents pharmacology
Vasopressins pharmacology
Intestines drug effects
Intestines physiopathology
Shock, Hemorrhagic drug therapy
Vasoconstrictor Agents therapeutic use
Vasopressins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9572
- Volume :
- 72
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Resuscitation
- Publication Type :
- Academic Journal
- Accession number :
- 17097209
- Full Text :
- https://doi.org/10.1016/j.resuscitation.2006.06.022