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Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study.
- Source :
-
BMC neurology [BMC Neurol] 2006 Nov 16; Vol. 6, pp. 41. Date of Electronic Publication: 2006 Nov 16. - Publication Year :
- 2006
-
Abstract
- Background: The etiology and pathophysiology of chronic fatigue syndrome (CFS) remain inchoate. Attempts to elucidate the pathophysiology must consider sleep physiology, as unrefreshing sleep is the most commonly reported of the 8 case-defining symptoms of CFS. Although published studies have consistently reported inefficient sleep and documented a variable occurrence of previously undiagnosed primary sleep disorders, they have not identified characteristic disturbances in sleep architecture or a distinctive pattern of polysomnographic abnormalities associated with CFS.<br />Methods: This study recruited CFS cases and non-fatigued controls from a population based study of CFS in Wichita, Kansas. Participants spent two nights in the research unit of a local hospital and underwent overnight polysomnographic and daytime multiple sleep latency testing in order to characterize sleep architecture.<br />Results: Approximately 18% of persons with CFS and 7% of asymptomatic controls were diagnosed with severe primary sleep disorders and were excluded from further analysis. These rates were not significantly different. Persons with CFS had a significantly higher mean frequency of obstructive apnea per hour (p = .003); however, the difference was not clinically meaningful. Other characteristics of sleep architecture did not differ between persons with CFS and controls.<br />Conclusion: Although disordered breathing during sleep may be associated with CFS, this study generally did not provide evidence that altered sleep architecture is a critical factor in CFS. Future studies should further scrutinize the relationship between subjective sleep quality relative to objective polysomnographic measures.
- Subjects :
- Case-Control Studies
Community Health Planning
Electroencephalography methods
Electromyography methods
Fatigue Syndrome, Chronic classification
Female
Humans
Male
Middle Aged
Narcolepsy physiopathology
Polysomnography methods
Retrospective Studies
Severity of Illness Index
Sleep Apnea Syndromes physiopathology
Fatigue Syndrome, Chronic epidemiology
Fatigue Syndrome, Chronic physiopathology
Sleep physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2377
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- BMC neurology
- Publication Type :
- Academic Journal
- Accession number :
- 17109739
- Full Text :
- https://doi.org/10.1186/1471-2377-6-41