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A randomized trial comparing two corticosteroid regimens combined with mycophenolate mofetil and cyclosporine for prevention of acute renal allograft rejection.
- Source :
-
Transplantation proceedings [Transplant Proc] 2006 Nov; Vol. 38 (9), pp. 2866-8. - Publication Year :
- 2006
-
Abstract
- Introduction: The launching of mycophenolate mofetil (MMF) has reduced the incidence of acute rejection episodes. We sought to evaluate the efficacy of decreasing the steroid dose.<br />Materials and Methods: This was a quasiexperimental, randomized, prospective trial. We enrolled 150 patients who received de novo renal transplantations from living or cadaveric donors, fulfilling the screening criteria. Patients were randomized to one of the following two arms: (A) MMF at a 2 g/d dose, cyclosporine (CsA) at a dose necessary to achieve target levels, and corticosteroids at the usual doses; (B) MMF at a 2 g/d dose, CsA at a dose necessary to achieve target levels, and corticosteroids at doses 50% lower than those of group A.<br />Results: Group A included 72 (48%) and group B, 78 patients (52%). There were no differences among the variables: leukopenia occurred in 11 patients in group A, and five patients in group B. Complications occurred in 67.4% (56) of group A, but only 32.6% (27) were related to infections. One case of urinary infection occurred in group B, while six occurred in group A. There was one case of acute rejection in group A, and none in group B. One graft loss occurred in group A. There were no differences in the remaining variables under study.<br />Discussion: The results showed an increased complication rate related to receiving usual steroid doses. There was no increase in acute rejection episodes among patients receiving 50% of the usual steroid dose.
- Subjects :
- Adrenal Cortex Hormones adverse effects
Cyclosporine adverse effects
Drug Therapy, Combination
Humans
Immunosuppressive Agents therapeutic use
Infections epidemiology
Leukopenia epidemiology
Mycophenolic Acid adverse effects
Mycophenolic Acid therapeutic use
Postoperative Complications epidemiology
Transplantation, Homologous immunology
Treatment Outcome
Adrenal Cortex Hormones therapeutic use
Cyclosporine therapeutic use
Graft Rejection prevention & control
Kidney Transplantation immunology
Mycophenolic Acid analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1345
- Volume :
- 38
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 17112851
- Full Text :
- https://doi.org/10.1016/j.transproceed.2006.08.138