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[Effects of traditional Chinese medicine on CD4 + T cell counts and HIV viral loads during structured treatment interruption in highly active antiretroviral therapy].
- Source :
-
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2006 Oct; Vol. 28 (5), pp. 658-61. - Publication Year :
- 2006
-
Abstract
- Objective: To explore the impacts of traditional Chinese medicine (TCM) on CD4 + T cell counts and human immunodeficiency virus (HIV) viral loads during the course of structured treatment interruption (STI) in highly active antiretroviral therapy (HAART).<br />Methods: Nineteen HIV/ADIS patients were treated for 14 months as follows: initiated with zidovudine/lamivudine + efavirdine for 6 months, then discontinued the therapy and treated with TCM instead for 2 months. HAART was then reinitiated for another 3 months, and then discontinued and replaced with TCM for another 3 months. The changes of CD4 + T cell counts and HIV viral loads were measured.<br />Results: During the first STI of HAART, 43.8% of patients had no viral rebounds one month later, and 62.6% had stable or increased immune functions; 18.8% had no viral rebounds two months later, and 43.8% had stable or increased immune functions. Changes of viral loads were not significantly different between these two months (P = 0.097), while CD4 + T cell counts significantly decreased two months later compared with one month later (P = 0.043). During the second STI of HAART, 33.3% of patients had no viral rebounds one month later, and 64.3% had stable or increased immune functions; 13.3% had no viral rebounds 3 months later and 46.6% had stable or increased immune functions. Changes of viral loads had significant difference (P = 0. 017), while CD4 + T cell counts at month 12 elevated significantly compared with the baseline (P = 0.014).<br />Conclusions: TCM can suppress the viral rebounds during STI-HAART, maintain immune functions. However, this effect may decrease along with the prolongation of STI-HAART.
- Subjects :
- Adult
Alkynes
Anti-HIV Agents administration & dosage
Antiretroviral Therapy, Highly Active
Benzoxazines therapeutic use
CD4 Lymphocyte Count
Cyclopropanes
Drug Therapy, Combination
Female
Follow-Up Studies
HIV Infections immunology
HIV Infections virology
Humans
Lamivudine therapeutic use
Male
Middle Aged
Time Factors
Treatment Outcome
Viral Load
Zidovudine therapeutic use
Anti-HIV Agents therapeutic use
Drugs, Chinese Herbal therapeutic use
HIV Infections drug therapy
Phytotherapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1000-503X
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
- Publication Type :
- Academic Journal
- Accession number :
- 17121226