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Therapeutic potential of interfering with apelin signalling.
- Source :
-
Drug discovery today [Drug Discov Today] 2006 Dec; Vol. 11 (23-24), pp. 1100-6. Date of Electronic Publication: 2006 Nov 02. - Publication Year :
- 2006
-
Abstract
- The apelin receptor is a G protein-coupled receptor activated by several apelin fragments. Its tissue distribution suggests that apelin signalling is involved in a broad range of physiological functions. Endothelial cells, which express high levels of apelin receptors, respond to apelin through the phosphorylation of key intracellular effectors associated with cell proliferation and migration. In addition, apelin is a mitogen for endothelial cells and exhibits angiogenic properties in matrigel experiments. This review focuses on the therapeutic potential of apelin signalling, which is associated with pathologies that result from decreased vascularisation (ischemias) or neovascularisation (retinopathies and solid tumors).
- Subjects :
- Apelin Receptors
Drug Design
Endothelium, Vascular drug effects
Endothelium, Vascular physiopathology
Humans
Neovascularization, Pathologic physiopathology
Neovascularization, Pathologic prevention & control
Receptors, G-Protein-Coupled antagonists & inhibitors
Signal Transduction drug effects
Receptors, G-Protein-Coupled physiology
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1359-6446
- Volume :
- 11
- Issue :
- 23-24
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 17129829
- Full Text :
- https://doi.org/10.1016/j.drudis.2006.10.011