Improved performance of a DNA nanomachine by cationic copolymers.

Authors :: Makita N
Inoue S
Akaike T
Maruyama A
Source :: Nucleic acids symposium series (2004) [Nucleic Acids Symp Ser (Oxf)] 2004 (48), pp. 173-4.
Publication Year :: 2004
Abstract: We have reported previously that the cationic comb-type copolymer, PLL-g-Dex, accelerated DNA strand exchange reaction while stabilizing DNA duplexes. In this research, we studied the effects of PLL-g-Dex on a DNA-fueled nanomachine. The copolymer enabled rapid and secure operations of the DNA nanomachine which utilized the structural transition between intramolecular G-quadruplex and intermolecular double helix.