Effects of natural suppressor cells on production of Th1 and Th2 cytokines and proliferation of polarized T cells.

Authors :: Bel'skaya NV
Bel'skii YP
Danilets MG
Trofimova ES
Sherstoboev EY
Agafonov VI
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Apr; Vol. 141 (4), pp. 440-3.
Publication Year :: 2006
Abstract: Natural suppressor cells from the bone marrow of intact animals and mice with Th1- and Th2-dependent immune response largely suppressed the production of Th1 (IFN-gamma, IL-2) and Th2 cytokines (IL-4). Antiproliferative activity of natural suppressor cells from intact and immunized animals was mediated by NO. Proliferation of Th1 cells was suppressed greater than that of Th2 cells. This selective effect of natural suppressor cells on the proliferation of target lymphocytes was due to higher stimulatory potential of Th1 cells (in comparison with Th2) towards natural suppressor cells.

Subjects :: Animals
Bone Marrow Cells metabolism
Cell Proliferation
Hydrogen-Ion Concentration
Immunosuppressive Agents pharmacology
Interleukin-2 metabolism
Interleukin-4 metabolism
Lymphocytes metabolism
Mice
Mice, Inbred BALB C
Cytokines metabolism
Gene Expression Regulation
T-Lymphocytes, Regulatory metabolism
Th1 Cells metabolism
Th2 Cells metabolism

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