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Synthesis and biological evaluation of some 6-substituted purines.

Authors :
Braga FG
Coimbra ES
de Oliveira Matos M
Lino Carmo AM
Cancio MD
da Silva AD
Source :
European journal of medicinal chemistry [Eur J Med Chem] 2007 Apr; Vol. 42 (4), pp. 530-7. Date of Electronic Publication: 2006 Dec 06.
Publication Year :
2007

Abstract

We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 [11,12] [corrected] 6-(3'-(thioethylamine)propylthio)purine 5, 6-(alpha-aceticacidthio)purine 7 and 6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine 14 with an IC(50)=50, 50, 39 and 29 microM, respectively.

Subjects

Subjects :
Animals
Ethylamines chemistry
Inhibitory Concentration 50
Macrophages drug effects
Mice
Molecular Structure
Parasitic Sensitivity Tests
Purines chemistry
Ethylamines chemical synthesis
Ethylamines pharmacology
Leishmania drug effects
Purines chemical synthesis
Purines pharmacology

Details

Language :
English
ISSN :
0223-5234
Volume :
42
Issue :
4
Database :
MEDLINE
Journal :
European journal of medicinal chemistry
Publication Type :
Academic Journal
Accession number :
17156894
Full Text :
https://doi.org/10.1016/j.ejmech.2006.10.014
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