Back to Search
Start Over
Acute and chronic effects of carbamazepine, phenytoin, valproate and vinpocetine on BAEP parameters and threshold in the guinea pig.
- Source :
-
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2007 Feb; Vol. 118 (2), pp. 420-6. Date of Electronic Publication: 2006 Dec 08. - Publication Year :
- 2007
-
Abstract
- Objective: To characterize the acute and chronic effects of the antiepileptic drugs (AEDs): carbamazepine (CBZ), phenytoin (PHT), valproic acid (VPA) and vinpocetine (VPC), at doses 20, 6, 30 and 2mg/kg, respectively, on the latencies and amplitudes of the waves of brainstem auditory evoked potentials (BAEPs) elicited by a supra-threshold stimulus alongside BAEP threshold.<br />Methods: BAEPs elicited by a stimulus of high (100dB nHL) intensity and BAEP thresholds were obtained at 4 and 8kHz: before, after the start of treatment, and following 28 days of a daily injection of the AEDs.<br />Results: After the start of treatment BAEPs were unchanged. After the long term treatment, CBZ and PHT increased P3 and P4 wave peak latencies and reduced P4 amplitude. Chronic VPA did not modify BAEP waves, and chronic VPC reduced P3 and P4 latencies. P1 and P2 were unchanged. BAEP thresholds at 4 and 8kHz were increased by CBZ, PHT and VPA, and decreased by VPC.<br />Conclusions: The chronic administration of several AEDs modifies BAEP waves of retro-cochlear origin.<br />Significance: Alterations in the generators of the later waves of BAEPs underlie, in most cases, the changes in hearing sensitivity produced by the long term treatment with AEDs at therapeutic relevant doses.
- Subjects :
- Acoustic Stimulation
Animals
Auditory Pathways physiology
Auditory Perception drug effects
Auditory Perception physiology
Auditory Threshold physiology
Brain Stem physiology
Carbamazepine pharmacology
Electrophysiology
Evoked Potentials, Auditory, Brain Stem physiology
Guinea Pigs
Male
Neural Conduction drug effects
Neural Conduction physiology
Phenytoin pharmacology
Reaction Time drug effects
Reaction Time physiology
Valproic Acid pharmacology
Vinca Alkaloids pharmacology
Anticonvulsants pharmacology
Auditory Pathways drug effects
Auditory Threshold drug effects
Brain Stem drug effects
Evoked Potentials, Auditory, Brain Stem drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1388-2457
- Volume :
- 118
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 17157555
- Full Text :
- https://doi.org/10.1016/j.clinph.2006.10.010