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Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators alone.
- Source :
-
Allergy and asthma proceedings [Allergy Asthma Proc] 2006 Nov-Dec; Vol. 27 (6), pp. 479-85. - Publication Year :
- 2006
-
Abstract
- Cough due to cough-variant asthma (CVA) responds well to bronchodilators such as beta 2 adrenergic agonists. The aim of this study was to assess longitudinal changes of pulmonary function and bronchial responsiveness in CVA, which was treated with bronchodilators alone. Seventeen CVA patients recorded intensity and frequency of cough every day. Spirometry and provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (PC20) were measured in the run-in period and after cough almost completely relieved on therapy. Cough score had improved within 2 weeks after the initiation of bronchodilator therapy. Forced expiratory volume in one second (FEV1) was significantly increased from 2.7 +/-0.7 L in the run-in period to 2.8+/-0.7 L after improvement of cough. However, the geometric mean (GSEM) PC20 value did not change from the run-in period [1542 (GSEM 1.29) microg/mL] to the time of improvement [2600 (GSEM 1.43) microg/mL]. Mildly increased bronchial responsiveness in CVA does not improve when only bronchodilator therapy is carried out. Because bronchial hyperresponsiveness has been shown to be a risk factor for typical asthma onset from CVA, the effect of inhaled corticosteroids on the longitudinal changes in bronchial responsiveness should be examined.
- Subjects :
- Asthma complications
Asthma physiopathology
Bronchi physiology
Bronchial Hyperreactivity drug therapy
Cough etiology
Cough physiopathology
Female
Humans
Longitudinal Studies
Lung physiology
Male
Middle Aged
Prospective Studies
Asthma drug therapy
Bronchi drug effects
Bronchodilator Agents therapeutic use
Cough drug therapy
Lung drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1088-5412
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Allergy and asthma proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 17176782
- Full Text :
- https://doi.org/10.2500/aap.2006.27.2884