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[Preparation of magnetic solid liposome nanoparticles of paclitaxel].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2006 Oct; Vol. 41 (10), pp. 933-8. - Publication Year :
- 2006
-
Abstract
- Aim: To study a new way to prepare high-dosage paclitaxel entrapped magnetic targeted nanoparticles and evaluate its quality.<br />Methods: Fe3O4 nanoparticles are prepared by co-depositing, at the same time ultrasonic is used to decrease soft agglomerate of nanoparticles and increase disperse level of it. The property of nanoparticles surface is improved to make the integrating of liposome and nanoparticle to be tighter. At last, paclitaxel entrapped magnetic solid liposome nanoparticles have been prepared by microemulsion-curing under low-temperature. The loading efficiency and encapsulating rate were determined by reverse-phase high-perfomance chromatography.<br />Results: The nanoparticles have spherical shape. Diameter of nanoparticle ranged from 150 nm to 170 nm. 98.29% of the drug is entrapped in the particle.<br />Conclusion: Magnetic susceptibility of nanoparticles is high, and the nanoparticles meet with the demand of targeted delivery system.
- Subjects :
- Antineoplastic Agents, Phytogenic administration & dosage
Antineoplastic Agents, Phytogenic chemistry
Drug Delivery Systems
Emulsions
Hydrogen-Ion Concentration
Liposomes
Nanoparticles administration & dosage
Paclitaxel administration & dosage
Particle Size
Temperature
Ultrasonics
Drug Compounding methods
Ferrosoferric Oxide chemistry
Nanoparticles chemistry
Paclitaxel chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 41
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 17184109