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Effects of growth hormone on growth, insulin resistance and related hormones (ghrelin, leptin and adiponectin) in Turner syndrome.

Authors :
Darendeliler F
Aycan Z
Cetinkaya E
Vidilisan S
Bas F
Bideci A
Demirel F
Darcan S
Buyukgebiz A
Yildiz M
Berberoglu M
Arslanoglu I
Bundak R
Source :
Hormone research [Horm Res] 2007; Vol. 68 (1), pp. 1-7. Date of Electronic Publication: 2007 Jan 05.
Publication Year :
2007

Abstract

Background: Concomitant evaluation of the metabolic and growth-promoting effects of growth hormone (GH) therapy in Turner syndrome (TS) may be used in the prediction of the growth response to GH therapy.<br />Aim: To evaluate the metabolic effects of GH therapy in TS and correlation with the short-term growth response.<br />Patients: 24 prepubertal children with TS, aged 9.4 +/- 2.6 years were followed for auxology and IGF-I, IGFBP-3, leptin, ghrelin, adiponectin, lipids and OGTT results in a prospective multicenter study.<br />Intervention: GH (Genotropin) in a dose of 50 microg/kg/day for 1 year.<br />Results: Height standard deviation score (SDS) increased from -3.9 +/- 1.5 to -3.5 +/- 1.4 (p = 0.000) on therapy. BMI did not change. IGF-I SDS increased from -2.3 +/- 0.4 to -1.6 +/- 1.1 at 3 and 6 months (p = 0.001) and decreased thereafter. Serum leptin decreased significantly from 2.3 +/- 3.9 to 1.7 +/- 5.3 ng/ml (p = 0.022) at 3 months and increased afterwards. Serum ghrelin decreased from 1.2 +/- 0.8 to 0.9 +/- 0.4 ng/ml (p = 0.005) with no change in adiponectin. Basal and stimulated insulin levels also increased significantly. Delta height SDS over 1 year showed a significant correlation with Delta IGF-I(0-3 months) (r = 0.450, p = 0.027).<br />Conclusion: IGF-I may be considered as a marker of growth response in TS at short term. Leptin shows a decrease at short term but does not have a correlation with growth response. The decrease in ghrelin in face of unchanged weight seems to be associated with increase in IGF-I and insulin levels. The unchanged adiponectin levels in spite of an increase in insulin levels indicates that adiponectin is mainly affected by weight, not insulin.<br /> (Copyright 2007 S. Karger AG, Basel.)

Details

Language :
English
ISSN :
1423-0046
Volume :
68
Issue :
1
Database :
MEDLINE
Journal :
Hormone research
Publication Type :
Academic Journal
Accession number :
17204837
Full Text :
https://doi.org/10.1159/000098440