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Effects of growth hormone on growth, insulin resistance and related hormones (ghrelin, leptin and adiponectin) in Turner syndrome.
- Source :
-
Hormone research [Horm Res] 2007; Vol. 68 (1), pp. 1-7. Date of Electronic Publication: 2007 Jan 05. - Publication Year :
- 2007
-
Abstract
- Background: Concomitant evaluation of the metabolic and growth-promoting effects of growth hormone (GH) therapy in Turner syndrome (TS) may be used in the prediction of the growth response to GH therapy.<br />Aim: To evaluate the metabolic effects of GH therapy in TS and correlation with the short-term growth response.<br />Patients: 24 prepubertal children with TS, aged 9.4 +/- 2.6 years were followed for auxology and IGF-I, IGFBP-3, leptin, ghrelin, adiponectin, lipids and OGTT results in a prospective multicenter study.<br />Intervention: GH (Genotropin) in a dose of 50 microg/kg/day for 1 year.<br />Results: Height standard deviation score (SDS) increased from -3.9 +/- 1.5 to -3.5 +/- 1.4 (p = 0.000) on therapy. BMI did not change. IGF-I SDS increased from -2.3 +/- 0.4 to -1.6 +/- 1.1 at 3 and 6 months (p = 0.001) and decreased thereafter. Serum leptin decreased significantly from 2.3 +/- 3.9 to 1.7 +/- 5.3 ng/ml (p = 0.022) at 3 months and increased afterwards. Serum ghrelin decreased from 1.2 +/- 0.8 to 0.9 +/- 0.4 ng/ml (p = 0.005) with no change in adiponectin. Basal and stimulated insulin levels also increased significantly. Delta height SDS over 1 year showed a significant correlation with Delta IGF-I(0-3 months) (r = 0.450, p = 0.027).<br />Conclusion: IGF-I may be considered as a marker of growth response in TS at short term. Leptin shows a decrease at short term but does not have a correlation with growth response. The decrease in ghrelin in face of unchanged weight seems to be associated with increase in IGF-I and insulin levels. The unchanged adiponectin levels in spite of an increase in insulin levels indicates that adiponectin is mainly affected by weight, not insulin.<br /> (Copyright 2007 S. Karger AG, Basel.)
- Subjects :
- Adiponectin blood
Child
Child, Preschool
Cholesterol blood
Female
Ghrelin
Human Growth Hormone pharmacology
Humans
Leptin blood
Peptide Hormones blood
Triglycerides blood
Turner Syndrome blood
Turner Syndrome physiopathology
Growth drug effects
Human Growth Hormone therapeutic use
Insulin Resistance
Peptide Hormones drug effects
Turner Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0046
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hormone research
- Publication Type :
- Academic Journal
- Accession number :
- 17204837
- Full Text :
- https://doi.org/10.1159/000098440