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Which has superior acid-suppressive effect, 10 mg omeprazole once daily or 20 mg famotidine twice daily? Effects of single or repeated administration in Japanese Helicobacter pylori-negative CYP2C19 extensive metabolizers.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2007 Feb; Vol. 52 (2), pp. 390-5. Date of Electronic Publication: 2007 Jan 09. - Publication Year :
- 2007
-
Abstract
- Low-dose omeprazole is superior to full-dose famotidine in maintenance therapy for gastroesophageal reflux disease, whereas "on-demand" famotidine is more effective for relief of episodes of heartburn. To explain this apparent discrepancy, intragastric pH was measured for 24-hr seven times in eight Japanese Helicobacter pylori-negative cytochrome P450 2C19 extensive metabolizers; on Days 1, 8, and 15 of repeated administration of 10 mg of omeprazole once daily and of 20 mg of famotidine twice daily and before medication. During repeated administration of omeprazole, mean intragastric pH and % time that intragastric pH > 4.0 were significantly higher and became greater. With famotidine, although these parameters were significantly higher, the degrees became smaller. Consequently, acid-suppressive effect was in the order; omeprazole < famotidine on Day 1, omeprazole approximately famotidine on Day 8, and omeprazole >famotidine on Day 15. This discrepancy possibly results from the "potentiation" of acid-suppressive effect of omeprazole and the "tolerance" phenomenon in respect to famotidine.
- Subjects :
- Administration, Oral
Adult
Anti-Ulcer Agents pharmacokinetics
Aryl Hydrocarbon Hydroxylases genetics
Asian People
Circadian Rhythm
Cross-Over Studies
Cytochrome P-450 CYP2C19
Drug Administration Schedule
Famotidine pharmacokinetics
Gastric Acidity Determination
Gastric Mucosa metabolism
Gastric Mucosa microbiology
Genotype
Humans
Mixed Function Oxygenases genetics
Omeprazole pharmacokinetics
Prospective Studies
Reference Values
Time Factors
Treatment Outcome
Anti-Ulcer Agents administration & dosage
Aryl Hydrocarbon Hydroxylases metabolism
Famotidine administration & dosage
Gastric Acid metabolism
Gastric Mucosa drug effects
Helicobacter pylori
Mixed Function Oxygenases metabolism
Omeprazole administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 17211705
- Full Text :
- https://doi.org/10.1007/s10620-006-9490-9