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Prevalence and risk factors of squamous intraepithelial lesions of the cervix among HIV-infected women - a long-term follow-up study in a low-prevalence population.
Prevalence and risk factors of squamous intraepithelial lesions of the cervix among HIV-infected women - a long-term follow-up study in a low-prevalence population.
- Source :
-
International journal of STD & AIDS [Int J STD AIDS] 2006 Dec; Vol. 17 (12), pp. 831-4. - Publication Year :
- 2006
-
Abstract
- HIV-infected women have high risk for precancerous lesions of the uterine cervix. We studied the prevalence and risk factors of squamous intraepithelial lesions (SIL) among systematically followed HIV-infected women enrolled from a population with low HIV prevalence. The study population consisted of 108 HIV-infected women enrolled between 1989 and 2003 with a mean follow-up 4.4 years. Risk factors of SIL were assessed based on samples collected during 2000-02. The overall rates of atypical glandular cells of uncertain significance (AGUS), atypical squamous cells of uncertain significance (ASCUS), low-grade SIL (LSIL) and high-grade SIL (HSIL) were 4, 24, 15 and 5%, respectively. Reduced CD4-lymphocyte count was associated with an increased prevalence of SIL, whereas duration of HIV infection (< or > or =5 years), use of antiretroviral medication, or HIV viral load (<50 or > or =50 copies/mL) was not. The cumulative risk of developing SIL after 1 and 5 years was 17% (95% confidence interval [CI] 7-27%) and 48% (95% CI 33-63%), respectively. The cumulative risk of SIL was increased among women younger than 31 years (P = 0.04) as well as in women displaying high initial HIV viral load (P = 0.01). Our results from a low HIV-incidence population re-emphasize the importance of guidelines for cytologic screening of HIV-seropositive women.
- Subjects :
- Adolescent
Adult
Anti-Retroviral Agents
Epithelial Cells pathology
Female
HIV Infections immunology
Humans
Middle Aged
Prevalence
Retrospective Studies
Risk Assessment
Risk Factors
Uterine Cervical Neoplasms etiology
Uterine Cervical Neoplasms pathology
Vaginal Smears
Uterine Cervical Dysplasia etiology
Uterine Cervical Dysplasia immunology
Cervix Uteri pathology
Follow-Up Studies
HIV Infections complications
Uterine Cervical Neoplasms epidemiology
Uterine Cervical Dysplasia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0956-4624
- Volume :
- 17
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of STD & AIDS
- Publication Type :
- Academic Journal
- Accession number :
- 17212861
- Full Text :
- https://doi.org/10.1258/095646206779307649