Back to Search
Start Over
Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2007 May 22; Vol. 111 (3), pp. 537-40. Date of Electronic Publication: 2006 Dec 28. - Publication Year :
- 2007
-
Abstract
- The in vivo antiplasmodial activity of the ethanol fruit extract of Tetrapleura tetraptera used as spice and in the treatment of various ailment in Niger Delta region of Nigeria was evaluated in Plasmodium berghei infected mice. Tetrapleura tetraptera (300-900 mg/kg day) exhibited significant (P < 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg day. The fruit extract possesses significant (P < 0.05) antiplasmodial activity with may have contributed to the immune status of the Nigerians against malaria in addition to its nutritive value.
- Subjects :
- Animals
Antimalarials administration & dosage
Chloroquine pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Fruit
Lethal Dose 50
Malaria mortality
Male
Medicine, African Traditional
Mice
Phytotherapy
Plant Extracts administration & dosage
Survival Rate
Toxicity Tests, Acute
Antimalarials pharmacology
Malaria drug therapy
Plant Extracts pharmacology
Plasmodium berghei drug effects
Tetrapleura
Subjects
Details
- Language :
- English
- ISSN :
- 0378-8741
- Volume :
- 111
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17236733
- Full Text :
- https://doi.org/10.1016/j.jep.2006.12.030