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Plasma concentrations of a type II collagen-derived peptide and its nitrated form in growing Ardenner sound horses and in horses suffering from juvenile digital degenerative osteoarthropathy.
- Source :
-
Veterinary research communications [Vet Res Commun] 2007 Jul; Vol. 31 (5), pp. 591-601. Date of Electronic Publication: 2007 Jan 24. - Publication Year :
- 2007
-
Abstract
- Several breeds of draft horses suffer from degenerative digital osteoarthropathy, resulting in a reduced active lifespan. A group of 30 Ardenner horses was followed, in standardized conditions, from 15 to 28 months of age to detect the early manifestations of the disease. The severity of the disease was assessed according to a personal grading system including clinical and radiographic items. Coll 2-1, a peptide of the helical region of type II collagen, and its nitrated form (Coll 2-1 NO(2)) were assayed in blood plasma collected at 452 +/- 18 days, 504 +/- 20 days, 558 +/- 18 days, 613 +/- 19 days, 675 +/- 19 days, 752 +/- 21 days and 852 +/- 19 days of age. At the end of the follow-up period, 53.3% of Ardenner horses were affected by a degenerative digital osteoarthropathy. A significant effect (p<0.05) of time, sex and pathology was observed for Coll 2-1 NO(2). Variations of Coll 2-1 were not significant except for the time effect. The elevation of Coll 2-1 NO(2) in the pathological group could indicate an inflammatory process during the growth of the affected horses, as nitration of tyrosine is mediated through reactive oxygen/nitrogen species and/or myeloperoxidase activity. Coll 2-1 NO(2) appears to be an interesting early marker of cartilage degradation and oxidation in degenerative osteoarthropathy.
- Subjects :
- Aging
Animals
Bone Diseases blood
Bone Diseases pathology
Female
Horse Diseases pathology
Horses growth & development
Joint Diseases blood
Joint Diseases pathology
Male
Sex Characteristics
Bone Diseases veterinary
Collagen Type II blood
Collagen Type II chemistry
Health
Horse Diseases blood
Horses blood
Joint Diseases veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0165-7380
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Veterinary research communications
- Publication Type :
- Academic Journal
- Accession number :
- 17252318
- Full Text :
- https://doi.org/10.1007/s11259-007-3518-2