Back to Search
Start Over
Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2007 Jun; Vol. 292 (6), pp. H3148-57. Date of Electronic Publication: 2007 Feb 02. - Publication Year :
- 2007
-
Abstract
- The accumulation of low-density lipoprotein (LDL) is recognized as one of the main contributors in atherogenesis. Mathematical models have been constructed to simulate mass transport in large arteries and the consequent lipid accumulation in the arterial wall. The objective of this study was to investigate the influences of wall shear stress and transmural pressure on LDL accumulation in the arterial wall by a multilayered, coupled lumen-wall model. The model employs the Navier-Stokes equations and Darcy's Law for fluid dynamics, convection-diffusion-reaction equations for mass balance, and Kedem-Katchalsky equations for interfacial coupling. To determine physiologically realistic model parameters, an optimization approach that searches optimal parameters based on experimental data was developed. Two sets of model parameters corresponding to different transmural pressures were found by the optimization approach using experimental data in the literature. Furthermore, a shear-dependent hydraulic conductivity relation reported previously was adopted. The integrated multilayered model was applied to an axisymmetric stenosis simulating an idealized, mildly stenosed coronary artery. The results show that low wall shear stress leads to focal LDL accumulation by weakening the convective clearance effect of transmural flow, whereas high transmural pressure, associated with hypertension, leads to global elevation of LDL concentration in the arterial wall by facilitating the passage of LDL through wall layers.
- Subjects :
- Animals
Atherosclerosis metabolism
Atherosclerosis pathology
Computer Simulation
Coronary Stenosis metabolism
Coronary Stenosis pathology
Coronary Vessels metabolism
Coronary Vessels pathology
Humans
Hypertension metabolism
Hypertension pathology
Severity of Illness Index
Stress, Mechanical
Atherosclerosis physiopathology
Blood Pressure
Coronary Stenosis physiopathology
Coronary Vessels physiopathology
Hypertension physiopathology
Lipoproteins, LDL metabolism
Models, Cardiovascular
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6135
- Volume :
- 292
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 17277019
- Full Text :
- https://doi.org/10.1152/ajpheart.01281.2006