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Discordant response of glutathione and thioredoxin systems in human hypertension?
- Source :
-
Antioxidants & redox signaling [Antioxid Redox Signal] 2007 Apr; Vol. 9 (4), pp. 507-14. - Publication Year :
- 2007
-
Abstract
- Hypertension is frequently associated with oxidative stress caused by high production of reactive oxygen species and compromised antioxidant defenses. Humans with essential hypertension, with or without treatment, and controls were examined (35 hypertensive and 30 normotensive). We noted a discordant response of the glutathione and thioredoxin systems in essential hypertension and to antihypertensive treatment. Further studies examining the significance of these thiols in hypertension outcomes are warranted.
- Subjects :
- Adult
Antioxidants metabolism
Female
Gene Expression
Glutathione blood
Glutathione metabolism
Humans
Hypertension blood
Hypertension metabolism
Male
Middle Aged
Oxidative Stress
RNA, Messenger genetics
RNA, Messenger metabolism
Thioredoxins blood
Thioredoxins metabolism
Glutathione genetics
Hypertension genetics
Thioredoxins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1523-0864
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Antioxidants & redox signaling
- Publication Type :
- Academic Journal
- Accession number :
- 17280491
- Full Text :
- https://doi.org/10.1089/ars.2006.1472