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Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Apr 01; Vol. 17 (7), pp. 1979-83. Date of Electronic Publication: 2007 Jan 19. - Publication Year :
- 2007
-
Abstract
- A library of potential antifungal triazole-modified beta-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17300931
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.01.021